Weight loss · San Diego

Weight loss in San Diego, built around your biology

Saffron & Sage offers Doctor-led weight loss care in San Diego. We start with your history, labs and hormones to find out why weight is holding on, then build a plan that can include nutrition, GLP-1 peptide therapy when it is appropriate, fitness, and support for sleep, stress and eating habits.

There is no set weight loss program here. Every plan is designed for one person, and we re-test to see what is working.

  • Physician-led clinic
  • Care coordinated across our team
  • HSA, FSA, HRA and LSA funds accepted
  • Best of San Diego, 2020, 2021, 2022
Led by
Doctors, not a template
Starts with
History, labs and the Integrative Physical
Peptides
When appropriate, after the first step and Saffron Panel
Re-tested
Every 90 days
Where
2555 State St, San Diego

New patients

Start with one visit

Your first visit looks at the whole picture: history, past attempts, labs and goals. Choose the first appointment alone, or add a full consultation.

Medical first appointment

First appointment

$250$300
  • Your first medical appointment
  • History, goals and a plan for what to test
  • HSA, FSA and LSA welcome
Book now
Best value · 50% off

Medical appointment + consultation

First appointment + consultation

$300$600
  • Your first medical appointment
  • A full consultation and health history, a $300 value, included
  • Lab review if you bring recent results
Book appointment + consultation

New patients. Through November 26, 2026. Labs and prescriptions are priced separately. HSA, FSA and LSA welcome. We are direct pay and do not bill insurance; superbills are available on request.

After your first visit

Book visits as you need them with medical credits, or save with a monthly plan. See monthly plans

Not sure where to start?

Talk it through on a free discovery call first. Book a discovery call

A Saffron & Sage Doctor performing an exam during a visit

Why weight holds on

Why weight holds on, even when you are doing everything right

You do not need a diagnosis to start. These are the reasons people most often come to us.

Weight that will not move

You eat well and exercise, and the scale has not changed. We look for what is getting in the way.

Hormone shifts

Perimenopause, menopause, low testosterone and PCOS can all change how your body stores weight.

Women’s Health →

Thyroid labs that say normal

A standard panel can miss a lot. A fuller panel shows more of the picture.

Free thyroid guide →

Blood sugar and insulin

Cravings, afternoon crashes and weight around the middle can point to how your body handles sugar.

Stress, sleep and cortisol

Poor sleep and constant stress change appetite and where weight settles.

How stress affects weight loss →

Cravings and emotional eating

Eating that is tied to stress or mood needs support for the stress, not just a meal plan.

Body shape, emotions and weight →

Gut and digestion

How well you digest and absorb food affects energy, inflammation and weight.

Gut health and weight loss →

Weight that keeps coming back

Regain after dieting, or after stopping a medication, deserves a plan for what comes next.

How care works

A plan built from your own data, not a program

01

Start with a conversation

Book a free discovery call, or a first visit with a full consultation. We review your history, past attempts and goals.

02

Test what is behind it

Labs that fit your history, plus the Integrative Physical for body composition and a full body assessment. Results take about two weeks.

03

Your written plan

A Doctor reviews everything with you and turns it into a plan: nutrition, targeted support, and medication if it is right for you.

04

Support and re-test

Ongoing visits and a re-check every 90 days, so the plan changes as you do.

Learn what happens at your first visit

A Saffron & Sage Doctor reviewing a patient’s history during a visit in San Diego

Peptides, when they are right for you

GLP-1 peptides, prescribed with care

GLP-1 peptides can help some people lose weight. They are not right for everyone, and they work best inside a plan. Dr. Nazanin and Dr. Alex prescribe them, explain the benefits and risks, and monitor you after you start. We coordinate with your primary care provider when you would like us to. Here is how it works:

  1. Complete a first step. Do the Integrative Physical or a Holistic Health Check-In.
  2. Complete your Saffron Panel. Have it done with us, or bring equivalent markers from the last 30 days. Not sure which markers count? Book a discovery call or call our Concierge.
  3. We book your Peptide Onboarding. Dr. Nazanin or Dr. Alex reviews everything with you and prescribes your peptides if they are right for you.
  4. Receive your peptides monthly. We dispense them each month.
  5. Add movement and food. Personal Training or Functional Fitness with Corey Butts, and Nutritional Therapy, alongside your peptides.
  6. Re-test every 90 days. We check your results and adjust.

About Peptide Therapy →

A Saffron & Sage Doctor talking with a patient

Care that works together

Services that play a part

Your plan uses only what fits you. These are the services our patients most often combine for weight loss.

Nutritional Therapy

Nutritional Therapy

Built on your labs and your food history, not the latest diet. Botanical Medicine supports digestion and cravings.

Nutritional Therapy →

Hormone support

Hormone support

Hormone Replacement Therapy for women and Testosterone Replacement Therapy for men, when your labs show a need.

HRT for women → TRT for men →

Diagnostic Testing

Diagnostic Testing

The data behind how you feel: thyroid, blood sugar, hormones, inflammation and nutrient levels.

Diagnostic Testing →

Acupuncture

Acupuncture

From Doctors of Acupuncture and Chinese Medicine, to support stress, sleep and digestion.

Acupuncture →

IV Therapy and Vitamin Injections

IV Therapy and Vitamin Injections

The Weight Loss IV and the Metabolism Vitamin Injection, for energy and metabolism while you make changes.

IV Therapy → Vitamin Injections →

Psychotherapy and Hypnotherapy

Psychotherapy and Hypnotherapy

Support for emotional eating, stress and the habits underneath them.

Psychotherapy → Hypnotherapy →

Peptide Therapy

Peptide Therapy

GLP-1 peptides, prescribed by Dr. Nazanin or Dr. Alex and dispensed monthly, with a re-test every 90 days.

Peptide Therapy →

Personal Training and Functional Fitness

Personal Training and Functional Fitness

One-on-one training with Corey Butts. All Personal Training and Functional Fitness happens at Bmorfit in Mission Valley, a full gym, and you can use your credits.

Movement Therapy →
A patient having her blood pressure checked at Saffron & Sage in San Diego

Your care team

The Doctors behind your plan

Your care team works together under one roof, overseen by our Medical Director. They are the Doctors who prescribe your peptides and review your labs.

Dr. Alexander Aponte-Davila, ND, MHSN, Naturopathic Doctor at Saffron & Sage

ND, MHSN

Dr. Alexander Aponte-Davila

Naturopathic Doctor and Nutritionist.

Read bio →
Dr. Nazanin Ghetmiri, ND, Naturopathic Doctor at Saffron & Sage

ND

Dr. Nazanin Ghetmiri

Naturopathic Doctor.

Read bio →

Book online

Book your first step

Choose a Holistic Health Check-In, Integrative Physical or Lab Interpretation, then pick a Doctor and a time. New patients, use the offer cards above. Peptide Onboarding is scheduled by our team after your first step and Saffron Panel; book a discovery call or call our Concierge at (619) 933-2340 to get started.

New to Saffron & Sage? Start with your first appointment for $250, normally $300.

Book now

Location

Weight loss care near Little Italy, San Diego

Saffron & Sage is in Mission Hills, just north of Little Italy, a short drive from Downtown, Bankers Hill, Point Loma and North Park. The entrance is on West Maple Street.

Hours: Monday and Thursday 8am to 2pm; Tuesday, Wednesday and Friday 8am to 8pm.

Saffron & Sage

2555 State St, Suite 101
San Diego, CA 92101

(619) 933-2340 · Get directions

Questions

Weight loss FAQs

Do you offer GLP-1 peptides for weight loss in San Diego?

Yes, when they are medically appropriate. To start, you complete the Integrative Physical or a Holistic Health Check-In and have your Saffron Panel done with us, or bring equivalent markers from the last 30 days. To find out which markers count, book a discovery call or call our Concierge. Then our team books your Peptide Onboarding visit with Dr. Nazanin or Dr. Alex, who prescribe the peptides. We dispense them monthly and re-test every 90 days. They are not right for everyone, and we will tell you if they are not right for you.

What does weight loss care at Saffron & Sage include?

It depends on you. Your plan can include nutrition, targeted testing, hormone support, GLP-1 peptides, Acupuncture, IV Therapy, Personal Training or Functional Fitness with Corey Butts, and support for stress and eating habits. There is no set program. Each plan is built from your own history and labs.

Why am I not losing weight when I eat well and exercise?

Hormones, thyroid function, blood sugar, stress, sleep and digestion can all keep weight in place. A Doctor looks at these together, with labs, rather than guessing. This is general information and not a diagnosis.

What tests do you run?

The tests depend on your history. They can include thyroid, blood sugar and insulin, hormones, inflammation and nutrient levels, and the Saffron Panel (up to 72 biomarkers). The Integrative Physical adds body composition and a full body assessment. Labs are billed separately.

Can I bring labs I already have?

Yes. Recent labs save time, and you can upload them for a free plain-language overview before your first visit. A Doctor reviews them with you.

How is this different from a weight loss clinic that only prescribes medication?

We look for why weight is holding on before we choose a tool. Peptides are one option among several, not the starting point. We re-test every 90 days and change the plan as your results change.

How fast will I lose weight?

It varies from person to person, and no honest clinic can promise a number. At your first visit we set realistic expectations based on your labs, your history and the options that fit you.

How much does it cost?

We review the cost of every step with you before you commit. You can book visits as you need them, or save with a monthly plan. Labs and your monthly peptides are priced separately from visits, and we go over both before you start.

Do you take insurance, and can I use my HSA or FSA?

We are a direct-pay clinic and do not bill insurance. We provide a superbill for eligible medical services, and a Letter of Medical Necessity when appropriate. We accept HSA, FSA, HRA and LSA funds. Your plan administrator decides which services are eligible, so please check with your plan. See how superbills and reimbursement work.

Where are you located?

2555 State Street, Suite 101, San Diego, CA 92101, just north of Little Italy. The entrance is on West Maple Street. Call (619) 933-2340.

Cover of the free Saffron & Sage thyroid guide

Free guide

Labs say normal. You don’t feel normal. Start here.

Our free thyroid guide explains what a standard panel can miss, which markers matter, and what to ask for at your next visit.

A Saffron & Sage Doctor during a patient visit in San Diego

Ready when you are

Start with one conversation

Tell us what is going on. We will point you to the right Doctor, or tell you honestly if something else should come first.

The content on this page is for educational purposes only and is not medical advice. Results vary from person to person. Prescription medication is only prescribed after a Doctor’s evaluation, when it is medically appropriate. We accept HSA, FSA, HRA and LSA funds. Your plan administrator decides which services are eligible, so please check with your plan. All medical services are provided by Kasawa Medical APC dba Saffron & Sage MD.

A Saffron & Sage Doctor meeting with a patient in our San Diego clinic