Vitamin Injections · San Diego
Vitamin Injections in San Diego: B12, Vitamin D, NAD+ and more
Intramuscular (IM) Vitamin Injections deliver micronutrients straight into muscle tissue, where they are absorbed into the bloodstream without depending on stomach acid, intrinsic factor or a healthy gut lining. For biohackers, busy professionals and anyone whose labs show low B12 or vitamin D, a 15-minute shot is one of the most efficient ways to close a nutrient gap.
At Saffron & Sage, every injection is reviewed by a licensed prescriber and given by our Registered Nurses or Naturopathic Doctors. Book a shot on its own, add one to your IV Therapy, or build a protocol around your Diagnostic Testing.
- B12 from $25, wellness blends $50
- 15-minute visits, or add to your IV
- Prescriber-reviewed, given by RNs and NDs
- Book online and pay at checkout
- HSA, FSA and LSA welcome, always gratuity-free
- Visit
- 15 minutes
- Cost
- B12 $25 · blends $50
- Practitioners
- Registered Nurses and Naturopathic Doctors
- Payment
- HSA, FSA and LSA welcome
- Where
- 2555 State St, San Diego
New patients
How much does Vitamin Injections cost? Two ways to start
Single Vitamin Injections are booked and paid for in the widget below: B12 is $25 and every other injection is $50. New patients who want a full health review and lab-guided protocol can start with a first appointment, or add a consultation.
1 medical credit
Your first Vitamin Injections appointment
- A health review with a Naturopathic Doctor
- Labs reviewed to see what you are actually low in
- A personalized injection protocol
Medical credit + consultation
First appointment + consultation
- Your first Vitamin Injections appointment
- A full consultation and health history, a $300 value, included
- Lab review if you bring recent results
New patients. Through November 26, 2026. Book online and pay at checkout. HSA, FSA and LSA welcome. We are direct pay and do not bill insurance; superbills are available on request.
After your first visit
Book single injections anytime, add them to IV Therapy, or save with a monthly plan from $275/month. See monthly plans
Not sure Vitamin Injections is right for you?
Talk it through on a free discovery call first. Book a discovery call
Why patients book
Why patients book Vitamin Injections
These are the reasons we hear most from people across San Diego, from Little Italy and Downtown to Mission Hills and North Park. Most start with labs, then use injections to correct what the numbers show.
Low energy and fatigue
Tired despite sleep, often with low or low-normal B12, ferritin or vitamin D on labs.
Brain fog and focus
B12 and B-complex vitamins are cofactors for neurotransmitter synthesis and myelin.
Poor absorption
Low stomach acid, PPIs, metformin, IBS or a plant-based diet all limit oral B12 absorption.
Immune resilience
Extra support through cold and flu season, travel and high-stress stretches.
Travel and jet lag
Before or after a long flight, to support immunity, hydration and recovery.
Pair with an IV drip →Metabolic and weight goals
Lipotropic and B-vitamin support alongside nutrition, training and labs.
Sleep and stress
Nutrients involved in GABA and melatonin pathways for a nervous system that won’t switch off.
Longevity and performance
NAD+ for cellular energy and healthy aging, as part of a lab-guided protocol.
The basics
What are Vitamin Injections, and how do they work?
Vitamin Injections are intramuscular shots, usually into the deltoid (upper arm) or the gluteal muscle. Muscle is highly vascular, so the nutrient enters circulation steadily over hours, bypassing the digestive tract entirely. Oral absorption of B12, for example, depends on stomach acid and intrinsic factor and saturates at about 1.5 mcg per meal; an IM dose does not.
B12 is a cofactor for methionine synthase and methylmalonyl-CoA mutase, two enzymes behind methylation, homocysteine clearance, myelin maintenance and red blood cell formation. Vitamin D works more like a hormone: the vitamin D receptor is found in immune cells, muscle and bone, and many people in San Diego still test insufficient because of sunscreen and indoor work.
NAD+ (nicotinamide adenine dinucleotide) carries electrons in mitochondrial energy production and is the fuel for sirtuins and PARP enzymes involved in DNA repair. Tissue NAD+ declines with age, which is why it has become a cornerstone of longevity protocols.
Vitamin Injections vs IV Therapy
An injection delivers a concentrated dose of one or a few nutrients in seconds. An IV drip delivers a larger volume with fluids and electrolytes over about an hour. Many patients use IV Therapy monthly and injections weekly in between, guided by Diagnostic Testing and Nutritional Therapy.
What it feels like
Quick, simple and over in minutes
The injection itself takes a few seconds. Most people feel a small pinch in the upper arm and some notice mild soreness at the site for a day. B12 can tint urine slightly pink-red for a day, which is harmless.
With B12, some people feel an energy lift within hours; with vitamin D and other nutrients, the effect builds over weeks as levels rise. Your Registered Nurse will tell you what to expect and how often to come back.
Tell us before your injection if you:
- Are pregnant or breastfeeding
- Take blood thinners or have a bleeding disorder
- Have allergies to vitamins, cobalt or preservatives
- Have kidney disease or Leber’s disease
Your visit
Your Vitamin Injections appointment, step by step
Book online
Choose your injection or add it to your IV appointment, pick a time and pay at checkout.
Complete your intake
Complete your intake online. A licensed prescriber reviews your health history before your first injection.
Your injection
Your Registered Nurse or Naturopathic Doctor checks in with you and gives your injection. The visit takes 15 minutes.
Your protocol
We recommend a rhythm, such as weekly B12 for a month or a seasonal immune series, and when to re-test your labs.
Choose your injection
Our Vitamin Injections
Each injection is a quick IM shot. B12 is $25 and every other blend is $50, booked and paid for online. Your nurse walks you through each formula’s ingredients before your injection.
$25
B12
The active cofactor for methylation, homocysteine clearance, myelin and red blood cell formation. Bypasses intrinsic-factor absorption, so it works when oral B12 does not. Often weekly for 4 weeks, then monthly.
$50
Vitamin D
A hormone-like vitamin that regulates calcium absorption, muscle function and innate immunity through the vitamin D receptor. Dosed against your 25-OH vitamin D level.
$50
Energy
A B-complex formula: B1, B2, B3, B5 and B6 are cofactors in glycolysis, the Krebs cycle and the electron transport chain where mitochondria make ATP.
$50
Immunity
Nutrients involved in innate and adaptive immune defence, such as vitamin C, zinc and B vitamins, for cold and flu season, travel and high-stress weeks.
$50
Metabolism
A lipotropic-style formula that supports fat metabolism in the liver and energy production, used alongside a nutrition and training plan.
$50
Beauty
Nutrients such as biotin and B vitamins that support keratin production for hair and nails and collagen-supporting pathways for skin.
$50
Detox
Support for phase II liver detoxification and glutathione-dependent antioxidant pathways, your body’s own clearance systems.
$50
Sleep
A calming formula built around nutrients such as magnesium and B6, cofactors in GABA, serotonin and melatonin synthesis.
Medical visit
NAD+
The coenzyme behind mitochondrial energy production and sirtuin-driven DNA repair, which declines with age. Usually a series over a few weeks; a brief warm flush is common.
NAD+ as an IV drip →Medical visit
Travel Immunity
A pre- and post-flight protocol to support immunity, hydration and recovery before, during and after a trip.
Medical visit
Weight management
Prescription support for body composition goals, with glucose and weight monitoring and labs every 90 days.
Free call
Build your protocol
Not sure which injections fit your labs and goals? Talk it through on a free discovery call first.
Book a free discovery call →Go further
Peptide injections and IV drips
Ready for more than a vitamin shot? Two places patients go next.
Physician-led
Peptide injections
Prescription peptide protocols for recovery, body composition, sleep and healthy aging, started only after a medical assessment and labs, with injection teaching and follow-up.
Explore Peptide Therapy →100% absorbed
IV drips
NAD+, Myers’, immunity, hydration and Doctor-directed drips delivered straight into the bloodstream with fluids and electrolytes, in our IV lounge.
Explore IV Therapy →Your practitioners
Meet our injection team
Vitamin Injections are reviewed by a licensed prescriber and given by our Registered Nurses and Naturopathic Doctors, overseen by our Medical Director.
ND, MHSN
Dr. Alexander Aponte-Davila
Naturopathic Doctor and Nutritionist. Labs, gut and hormone health, nutrition, peptides and IV care.
Read bio →
ND
Dr. Nazanin Ghetmiri
Naturopathic Doctor. Gut, endocrine and women’s health, hormones, Microneedling and IV care.
Read bio →
RN
Karen Catalano
Registered Nurse. Vitamin Injections and IV care, from intake to aftercare.
RN
Karissa Agosto
Registered Nurse. Vitamin Injections and IV care, from intake to aftercare.
Book online
Book your Vitamin Injections
Choose your injection, pick your practitioner and a time, then pay at checkout. New patients who want a full health review can start with the $250 first appointment below.
New to Saffron & Sage? Start with your first appointment for $250, normally $300.
Book now
Location
Vitamin Injections near Little Italy, San Diego
Saffron & Sage is in Mission Hills, just north of Little Italy, a short drive from Downtown, Bankers Hill, Point Loma and North Park. Many patients come in before or after work.
Hours: Monday and Thursday 8am to 2pm; Tuesday, Wednesday and Friday 8am to 8pm.
Questions
Vitamin Injections FAQs
How much does Vitamin Injections cost in San Diego at Saffron & Sage?
At Saffron & Sage, a B12 injection is $25 and every other Vitamin Injection is $50, booked online with payment at checkout. You can book a shot on its own as a 15-minute visit or add it to your IV Therapy. New patients who want a full health review can book a first appointment for $250 (normally $300). HSA, FSA and LSA dollars are welcome.
Which Vitamin Injection should I choose?
It depends on your goals and labs. B12 and Vitamin D are the most common starting points. Ask our team when you book, or have a Naturopathic Doctor review your labs first.
Are B12 injections better than B12 pills?
For people who absorb poorly, yes. Oral B12 needs stomach acid and intrinsic factor, and absorption is limited per dose. IM B12 bypasses the gut, which is why it is standard care for B12 deficiency and pernicious anemia.
How often should I get a B12 injection?
Many people start with weekly injections for the first month, then maintenance every few weeks. Your practitioner will recommend a rhythm based on your symptoms and labs.
How long do the effects last?
It depends on the nutrient and your levels. B12 is stored in the liver, so a correction can last weeks; water-soluble blends are used more often. Re-testing shows whether your levels are holding.
Vitamin Injections or IV Therapy: which is better?
They do different jobs. An injection is a quick, concentrated dose of a few nutrients. An IV drip delivers more nutrients plus fluids over about an hour. Many patients combine the two.
Do Vitamin Injections hurt?
Most people feel a small pinch in the upper arm. Some notice mild soreness at the site for a day.
What is an NAD+ injection?
NAD+ is a coenzyme your cells use to make energy and repair DNA, and levels fall with age. NAD+ injections are usually given as a series over a few weeks. A brief warm or flushed feeling is common and passes quickly.
Can I add an injection to my IV?
Yes. Add any injection when you book your IV Therapy, or ask your nurse on the day.
Who gives the injections?
Our Registered Nurses and Naturopathic Doctors, after a licensed prescriber reviews your health history.
Do I need labs first?
Not for most Vitamin Injections. Labs are required for prescription protocols such as weight management, peptides and TRT, and are a good idea if you want to know whether you are actually low.
How do I book Vitamin Injections?
Book online on this page: choose your appointment, pick your practitioner and a time, and pay at checkout. New patients can start with the $250 first appointment. You can also call (619) 933-2340.
Is Vitamin Injections covered by insurance or HSA?
We accept HSA, FSA, HRA and LSA funds. Your plan administrator decides which services are eligible, so please check with your plan. We are direct pay and do not bill insurance; superbills are available on request.
Do I need to be a member?
No. Anyone can book Vitamin Injections online and pay at checkout. Membership unlocks preferred pricing, member-only offers and events, and other perks.
Where are you located?
2555 State Street, Suite 101, San Diego, CA 92101, just north of Little Italy. The entrance is on West Maple Street. Call (619) 933-2340.
Free guide
Use the health money you already set aside.
Our free guide to using HSA and FSA dollars for your care. The current limits, the rules that changed for 2026, and the traps that quietly cost people money. Not tax advice.
- HSA, FSA and HRA: how they differ
- The rules that changed for 2026
- Five traps that quietly cost people money
Keep reading
More on Vitamin Injections
Ready when you are
Book your first Vitamin Injections appointment
Start with a single first appointment for $250, or add a full consultation for $300, normally $600. Not sure yet? Our team will listen, explain your options and help you pick the right appointment and practitioner.
All medical services are provided by Kasawa Medical APC dba Saffron & Sage MD. Vitamin Injections are given after a licensed prescriber reviews your health history. They are not a substitute for a balanced diet or medical care and are not intended to diagnose, treat, cure or prevent any disease. Please tell us about pregnancy, allergies, bleeding disorders and all medications. If you have a severe reaction or trouble breathing, call 911.